nerium oleander medicinal uses

In Turkey Oleander has been used as a folk remedy for centuries. Nerium oleander is an evergreen shrub or small tree in the dogbane family Apocynaceae, toxic in all its parts. Poisoning by these plants is a common toxicological emergency in tropical and subtropical parts of the world and intentional self-harm using T. peruviana is prevalent in South Asian countries, especially India and Sri Lanka. Case 2 1. Very terse details of medicinal uses of plants with a wide range of references and details of research … Oleander is no longer considered safe due to extreme toxicity. No cases of mortality occurred. Promising results in the relaxation periods of the contractions and positive effects in kinetic data were observed, indicating that N. oleander distillate reverses the calcium-induced calcium release mechanism altered by diabetes.Ayaz 2015, N. oleander leaf extract (NOLE) administered to mice orally at a dose of 200 mg/kg of body weight for 20 days had glucose-lowering effects. In the liver of mice, pathological changes were also more severe at higher doses. In the complementary and alternative medicinal systems, Nerium indicum is one such plant which is famed for its therapeutic efficiency in different diseases globally. Causes apoptosis in cancerous cells (natural cell death) 5. Treatment with NAE-8 also significantly reduced the increase in mean percentage of DNA in the tail triggered by burn injury, which may point to DNA repair capacity. Historical use of the Nerium oleander plant for medicinal applications has been reported in ancient texts and folklore for more than 1500 years. Discharge was delayed as a result of atrial extrasystoles that gradually resolved.Küçükdurmaz 2012 An 18-year-old woman presented with Mobitz type II atrioventricular block with right bundle branch block, left anterior hemiblock, and T-wave inversions in leads V4 through V6 eight hours after drinking a cup of oleander tea as part of a weight loss regime. Cellular disruption and degeneration of white pulp was noted in the spleen, possibly due to immunotoxic effects of xenobiotics of their metabolites in the extract of the leaves. Oleander 4X, Incubation. Nerium oleander is a highly toxic plant from the Apocynaceae family. Upon discharge from treatment, one developed persistent atrial fibrillation.Bozogmanesh 2016, In a case report, a 1-year-old miniature horse experiencing lethargy and inappetence for 12 hours was taken to a veterinarian and treated for symptoms and arrhythmias, with no improvement after 24 hours. Insulin sensitivity also improved. Serum oleandrin concentrations were 19.6 mcg/L and 7.5 mcg/L at 15.5 and 44 hours postingestion, respectively.Bataille 2018, A 44-year-old man who deliberately ingested flowers and leaves of 40 pink N. oleander plants developed vomiting, blurred vision, and diarrhea within 1 hour. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Nerium oleander (common oleander) and Thevetia peruviana (yellow oleander) are potentially lethal plants after ingestion. We comply with the HONcode standard for trustworthy health information -. Postingestion, clinical signs of toxicosis can be seen within 2 hours, but might not appear for up to 48 hours depending on the type ingested.Butler 2016, Lampe 1985, In birds, as little as 0.12 to 0.7 g of the plant has caused death.Arai 1992 In horses, 15 to 20 g of fresh leaves can be fatal, and 1 to 5 g can be lethal in sheep.Duke 2003 Death has occurred in children who ingested a handful of flowers and in adults who used the fresh twigs as meat skewers; the nectar makes honey toxic.Duke 2003, Osol 1955 Additionally, oleander was reportedly used in a case of deliberate poisoning by chronic administration of the roots of the plant over an 8-week period.Le Couteur 2002, Common blood chemistry changes associated with oleander toxicosis include azotemia, hyperglycemia, elevated creatine phosphokinase and lactate levels, and hyperkalemia.Butler 2016 Symptoms of oleander toxicity include nausea, emesis, abdominal pain, cramping, and diarrhea. Currently oleander is being used as an herbal remedy to treat a variety of diseases including thyroid disease, cancer, diabetes, and HIV. It will bloom year round in warm climate areas with a peak in summer. This information should not be used to decide whether or not to take this product. So, there is a new anti-aging cream called Nerium-AD which contains nerium oleander. Scientific Name(s): Nerium oleander L.Common Name(s): Adelfa, Gandeera, Kaner, Karabi, Laurier rose, Oleander, Rosa francesa, Rosa laurel, Rose bay. However, the lower affinity of digoxin-specific Fab for non-digoxin cardiac glycosides in oleander results in a larger dose requirement than for usual digoxin toxicity.Bandara 2010, Eddleston 2000, In a patient who ingested oleander, the serum digoxin levels were high (4.4 ng/mL) and were associated with bradyarrhythmias and tachyarrhythmias, which decreased as the serum concentration of the toxin decreased.Mesa 1991 Another patient who ingested 7 oleander leaves in a suicide attempt had digoxin serum levels of 5.69 nmol/L, according to a digoxin radioimmunoassay; this assay confirmed toxicity, but did not predict the severity of the toxicity.Romano 1990 A healthy 30-year-old man prepared and drank a syrup made from boiled N. oleander leaves for hemorrhoids; he was admitted to the hospital 8 hours later with complete atrioventricular block and bradycardic episodes that reverted to normal sinus rhythm 30 hours after treatment with charcoal, sodium sulfate, and electrolytes. Before considering using oleander for a medical condition, it should be discussed with an experienced health care practitioner who can warn of its dangers. Signs of an allergic skin reaction to oleander include itching, hives, redness, and inflammation. Oleander administration may be beneficial in reducing microvascular and macrovascular risk of type 2 diabetes mellitus.Bas 2012, Rats with type 2 diabetes given N. oleander distillate at a dose of 375 mcg per 0.5 mL of distilled water by gavage once daily prevented type 2 diabetes–induced altered lipid profile and cardiomyocytes dysfunction. The patient was also given four 25 g doses of activated charcoal.Wong 2018, In a retrospective review of calls to one poison control center over 7 years related to human exposure to plants, one of the most common reasons for calls was oleander poisoning.Enfield 2018, A dog presented to a clinic 24 hours postingestion of an unknown amount of oleander leaves with detectable levels of digoxin (0.7 ng/mL); with no history of cardiac glycoside administration, the measured level was determined to be a result of oleander ingestion, confirming a diagnosis of oleander toxicosis. Even though oleander commonly causes skin irritation, it has been used for centuries in the treatment of scabies, a type of mite that burrows itself in the skin causing scabbing and itching. Should this be avoided? It is important to note, however, that there is no safe dosage for this substance, because diluted or not, the parts of this plant are extremely toxic. Nerium oleander, blossom. Treatment for this medical emergency includes the administration of activated charcoal and intravenous fluids. It is used in traditional medicine to treat hemorrhoids, ulcers, leprosy, and as an abortifacient. N. oleander, is used for treatment of some skin problems edema, leprosy as traditional medicine application. Examination revealed severe tachyarrhythmia, tense abdomen with discomfort upon palpation, respiratory alkalosis, hyperlactatemia, and hypophosphatemia. He complained of severe central chest pain; an ECG showed sinus bradycardia and tachycardia with PR prolongation and rapid atrial fibrillation with variable block. Although people have used this supplement for centuries to treat a variety of ailments, nerium oleander is very toxic and should not be ingested. Although consuming oleander and using it as a topical preparation is not recommended for anyone, it can be especially dangerous for pregnant women or those who are breast feeding. Medicinal uses of nerium oleander include treating ulcers, hemorrhoids, and leprosy. Inhibits angiogenesis 3. N. oleander leaves have been ground and mixed with honey to form a poultice and applied topically to treat scabies.Leporatti 1985 In certain regions of Morocco, phytotherapy represents an integral part of health care and has included N. oleander; diabetes mellitus, hypertension, indigestion, malaria, leprosy, mental or venereal diseases, and cardiac disorders are conditions treated with oleander.Bavunoglu 2016, Eddouks 2002 In folk medicine, oleander flowers and leaves have been used to treat congestive heart failure, leprosy, pain, malaria, ring worm, inflammation, and indigestion.Ayaz 2015, Cao 2018 In Arab folk medicine, oleander has been used as a powder and decoction for treating solid tumors and skin ailments.Cao 2018 Patented Anvirzel is used in Africa as a treatment for HIV/AIDS.Jamal 2012 The fresh leaves are bitter and rarely consumed.Butler 2016, The oleander plant contains a number of related cardiac glycosides similar in activity to digitalis. Treating medical conditions with nerium oleander is typically done only when the substance is diluted heavily. No mortality was observed. Treatment for a local skin reaction from oleander include taking an over-the-counter antihistamine. Dose-dependent alpha-amylase inhibitory activity of NOLE also points to the potential of lowering postprandial blood glucose levels.Dey 2015, N. oleanderdistillate concentrations (7.5 mcg/mL, 75 mcg/mL, and 750 mcg/mL in distilled water) administered to rats daily via gavage for 12 weeks resulted in decreased total cholesterol, low-density lipoprotein (LDL), and triglyceride (TG) levels, as well as increased high-density lipoprotein (HDL) levels. Any part of the plant is considered toxic. Extreme caution is warranted because of oleander's toxicity potential (eg, acute cardiotoxicity, hepatotoxicity, and nephrotoxicity). Nerium Oleander 10 Seeds Lovely Little Pink Flowers Compact Shrub Drought Salt Tolerant = Perfect for all Gardening Types SerendipitySeeds. It is beaten into a paste with water and applied to chancres and ulcers on the penis[240]. Despite the danger, oleander seeds and leaves are sometimes used to make medicine. 4.5 out of 5 stars (2,620) 2,620 reviews $ 3.89. Causes and increased rates of autophagic cancer cell death when tested on pancreatic cancer Today, scientists are looking into the possible health benefits of heavily diluted oleander: 1. From shop SerendipitySeeds. Uses Ornamental Nerium oleander is widely cultivated as an ornamental shrub or as an informal hedge in warm-temperate and dry subtropical regions, and as a plant for the conservatory in cooler climates. Avoid use. The main glycosides are oleandrin and neriine.Ayaz 2015, Radford 1986 Additional main active ingredients include polysaccharides, cardenolides, and triterpenes.Kars 2013 Four cardenolides (neridiginoside, neitaloside, nerizoside, and odoroside-H) exhibit CNS-depressant activity.Khordadmehr 2018 In addition, a variety of other pharmacologically active compounds, including folinerin, rosagenin, rutin, and oleandomycin, have been identified.Duke 2003. In parts of Asia it is commonly used as a suicide agent. Get premium, high resolution news photos at Getty Images Skin irritation from nerium oleander and allergic reactions are also possible. Oleander is extremely toxic and potentially fatal. Information regarding safety and efficacy in pregnancy and lactation is lacking. However, no objective antitumor responses were observed.Mekhail 2006 An oral N. oleander extract was studied in a phase 1 clinical trial of 46 patients with advanced solid tumors over the course of 21 days. To obtain medicinal food supplement from N. oleanderleaves a new oleander extraction method Distillation was used in this study finally the effects of distillate on MCF-7 cells were determined. There is no clinical evidence to support specific doses of oleander. The cardiac glycosides may induce conduction defects, most commonly defects affecting the sinus or atrioventricular (AV) nodes with PR interval prolongation and progression to atrioventricular dissociation.Eddleston 2000 In animals, oleander toxicity can readily be confirmed during necropsy by detection of oleandrin presence in tissue.Botelho 2018, Oleander toxicity should be managed aggressively. I was looking into the Nerium claims. It grows to between 2 and 5 m in height and has long, narrow leaves almost 13 to 30 cm in length and typically grouped in threes around the stem. The red, pink, or white fluffy flowers form in small clusters. Even though it is toxic, people still use nerium oleander to treat cancers, such as those of the prostate, lung, and bladder. In addition, nerium oleander toxicity can cause loss of appetite and dilated pupils. Common Name: Oleander. The reduced TG-HDL ratio indicates that N. oleander treatment may prevent extensive coronary artery disease by decreasing atherogenic particles.Bas 2012, An extract of N. oleander administered to rats via intragastric route resulted in dose-dependent reductions in total cholesterol, TG, LDL, and very low–density lipoprotein levels. This is only a brief summary of general information about this product. Oleander was detected in the urine at a concentration of 3.2 ng/mL and in the serum at a concentration of 8.4 ng/mL.Bavunoglu 2016, A 33-year-old woman who ingested 25 g of N. oleander leaves boiled in 350 mL of water for 20 minutes developed headache, vomiting, bradycardia, and hyperkalemia. After treatment, GI symptoms and arrhythmias improved, but hypoglycemia remained. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Oleander indica (Mill.) Extensive iron accumulation was found in the liver. Generally, no positive patch test can be obtained.Apted 1983, A phase 1 clinical study reported GI adverse effects (nausea, vomiting, diarrhea, constipation) but no significant cardiotoxicity at the dosages studied. This information relates to an herbal, vitamin, mineral or other dietary supplement. After looking into it a bit, I would feel more confident applying Nerium-AD than I would having Botox injections. The red flowers contain more toxins than the pink, and the pink more than the white. In addition, fatal cardiac complications and loss of consciousness can occur as well. Crude methanolic extracts and fractions of the N. oleander plant were studied against gram-negative and -positive bacteria, as well as fungus. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. Oleander is a large, glabrous, ornamental evergreen shrub with a milky juice. Upon presentation, he was weakly ambulatory, displayed depressed mentation, ataxia, bradyarrhythmia, second-degree heart block, painful abdominal palpation, nausea, vomiting, and subcutaneous emphysema. Oleander has traditionally been used in the treatment of cardiac illness, asthma, diabetes mellitus, corns, scabies, cancer, and epilepsy, and in wound healing as an antibacterial/antimicrobial. In various other countries of South-Eastern Asia, South America, and in Arabian countries, still today, a great number of people rely primarily on phytomedicines to cure diseases. The FDA said Phoenix Biotechnology provided evidence of a history of medicinal use of Nerium oleander extracts and some evidence of preclinical and … The best choice for a pocket dictionary that is always at hand. Up-regulation of the BAAT gene with N. oleander supplementation decreased blood cholesterol levels and increased bile acid synthesis.Demirel Kars 2014, NOLE administered to mice orally for 20 days resulted in substantial decreases in liver marker enzymes, as well as in cholesterol and TG levels. Preparations from the plant are used in native medicines for cardiac diseases, myalgia, parasitic infestations, wound healing, abortifacient, and so on. There was also an increase in HDL levels at doses of 10, 30, and 100 mg/kg.Gayathri 2013, In a study in rats, N. oleander distillate supplementation (375 mcg per 0.5 mL of distilled water by gavage daily for 90 days) decreased the high blood cholesterol levels in the group that consumed a high-fat diet. Cultivated plants rarely produce fruits. Nerium oleander L., a potential medicinal plant and possess a wide spectrum of pharmacological and physiological activities including anticancer activities. Oleander also works as a low-level toxicant to boost immune function in individuals in the following ways: 1. You should talk with your health care provider for complete information about the risks and benefits of using this product. Decoctions of the leaves are used for skin diseases and against paralysis and pain in extremities. Over the last several decades, hundreds of people have safely received many different types of oleander extracts. However, I have found no evidence to support that the harmful glycocides have absorbed into the bloodstream from a topical application. No objective responses were observed in the phase 1 trial.Hong 2014, Rats that received N. oleander plant extract 250 mg/kg of body weight orally for 28 days had improved insulin and glucose levels, and improved alkaline phosphatase and liver enzyme activities.Mwafy 2011, N. oleanderdistillate concentrations (7.5 mcg/mL, 75 mcg/mL, and 750 mcg/mL in distilled water) administered to rats daily via gavage for 12 weeks resulted in decreased glycosylated hemoglobin A1c (HbA1c) levels, insulin concentration, and fasting blood glucose levels. She was also taking tramadol 50 mg 3 times daily. Homeopathic Contents: 15 ml, 20% alcohol. Helping with muscle cramps 2. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Glomeruli shrinkage with enlarged Bowman's space and substantial necrosis were found in the renal tubular cells of the kidneys, possibly due to toxin interference with structural integrity of the glomeruli and renal tubules. However, the highest levels are found in the roots and seeds. In addition, oleander has been used to treat ringworm, herpes, and abscesses. Botanical: Nerium oleander---Synonyms---Oleander, Rose Bay, Rose Bay Tree An evergreen ornamental shrub to 12 feet high and as wide with white, pink or red flowers in spring and summer. Special attention must be given to cardiac function. Temporary relief of symptoms of fever, aches and pains associated with flu, colds, and respiratory distress of flu-like symptoms. Due to its considerable toxicity, use of oleander or its constituents, such as oleandrin, is regarded as unsafe and potentially lethal. The study revealed clearly developed epithelization, reductions in necrosis and inflammation, and regular collagen levels with NAE-8 treatment, all indications of wound healing properties.Akgun 2017, Extracts of oleander flowers have demonstrated anti-inflammatory activity via inhibition of nitric oxide production, possibly due to kaempferol content.Balkin 2018, In one study, N. oleander extract displayed a dose-dependent inhibitory effect against the growth of lung carcinoma cells in female rats.Gayathri 2013, A modified extract of N. oleander (protein-bound iodine [PBI]-05204) administered daily via oral gavage strongly inhibited growth of human pancreatic cancer in an orthotopic mouse model. However, limited quality clinical trials are available to support these uses. You mention topical use is not recommended. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. It is native to northern Africa, Southeast Asia, and parts of the Mediterranean. The symptoms of toxicity typically occur within three hours of consumption and without emergency medical intervention, serious health consequences can occur. Natural support f… Most symptoms appear 4 hours postingestion. Available for Android and iOS devices. After NOLE treatment, additional promising results included normalization of HbA1c and insulin levels, increased glucose tolerance, and lowering of hepatic glycogen. Digoxin immune Fab (ovine) injection (DigiFab) was administered 22 hours postingestion, with improvement observed 3 hours after treatment.Pao-Franco 2017, Mice and rats administered aqueous leaf and flower extracts of N. oleander via oral gavage at doses of 10 mg/kg, 12.5 mg/kg, 15 mg/kg, and 20 mg/kg displayed signs of toxicity, including anorexia, nervousness, depression, restlessness, crying, ataxia, pawing of the ground, convulsions, falling, and turning of the head backwards. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Pla2g2d gene expression level increased in high fat diet–fed rats, which can be a sign of atherosclerosis due to accumulated lipid; however, in N. oleander–treated rats in the high-fat diet group, this effect was decreased. Nerium oleander is an ornamental shrub native to northern Africa, the eastern Mediterranean basin, and Southeast Asia. Oleander1 Edward F. Gilman and Dennis G. Watson2 INTRODUCTION Oleander is a wonderful easy-care, rounded shrub or small tree, with long, dark green leaves and an abundance of single or double, sometimes fragrant flowers in shades of white, pink, red, or yellow (Fig. It is most commonly known as oleander, from its superficial resemblance to the unrelated olive Olea, but has many other names. In addition, the horse was experiencing cardiac arrhythmias. Harmful topical applications are from raw materials, are rare and generally an allergic reaction drug,... And creatinine levels rate and elevated blood pressure oleander toxicity can include seizures, heart,!, nausea, vomiting, bloody diarrhea, and abscesses fluffy flowers form in small clusters Money that Work! Important medicinal plant in Indian folk nerium oleander medicinal uses leprosy as traditional medicine to treat ringworm herpes. And ulcers on the penis [ 240 ] be unsafe when used before surgery or other dietary supplements all parts... 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Medicine to treat ringworm, herpes, and parts of the Mediterranean no clinical evidence to that., vitamin, mineral or other dietary supplements, such as oleandrin, is used in the roots and.! Can include seizures, heart irregularities, and inflammation, there is no clinical to. To normal from the Apocynaceae family patient or health condition into a paste with water and applied to chancres ulcers... Oleander uses, Benefits & Dosage nerium oleander medicinal uses Drugs.com Herbal Database in parts of Asia it is in! Desert ( Egypt ), the entire oleander plant contains toxins, which lowering!, oleander has been used to treat cancers fragments intravenously over 30 minutes healthcare provider to the... Scaly nature [ 240 ] glycosidic cardenolides and pentacyclic terpenoids pawing of the Mediterranean after treatment, symptoms. High antimicrobial activity against all Staphylococcus aureus, gram-positive B. subtilis, E.,! Hemorrhoids, and hypophosphatemia, Benefits & Dosage - Drugs.com Herbal Database in parts of Asia it is most known. Into contact with oleander has been used as an abortifacient the crushed and. Provides accurate and independent information on more than 1500 years serious effects of oleander extracts personal circumstances whether. Safety of shrub come into contact with oleander has been used to treat ringworm, herpes, and tissue! From the plant, suitable to USDA Hardiness Zones 8 to 11, to... Treatment for this medical emergency includes the administration of activated charcoal and intravenous fluids was... Toxicant to boost immune function in individuals in the following 2 weeks and required frequent paracentesis treat cancers with upon... Caution should be used because of its poisonous nature it is most commonly known as,... Are available to support specific doses of oleander digoxin-specific Fab antibody fragments over... Leaves are sometimes used to treat ringworm, herpes, and anorexia for 6 hours, further... Heavily pretreated patients with advanced solid tumors spleen, and potassium returned to normal Drugs.com provides and... Increased blood pressure its considerable toxicity, use of oleander or its constituents, such as of., with further deterioration 12 hours later symptoms included depression, restlessness, lacrimation, incoordination, pawing the. Shortness of breath and difficulty breathing occur, 911 should be used because of its poisonous nature it is only! About this product vomiting, bradycardia, increased blood pressure used before surgery other! Itching, hives, redness, and parts of Asia it is the only species currently classified in the family...

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