avicennia marina extract

Transl Res. Increased inflammatory cytokines also have inhibitory effects on the glucose transporter type 4 (GLUT-4) gene, leading to increased insulin resistance (6). How to Cite: 2016;7(3):75-9. doi: 10.4103/0976-0105.183262. The results revealed that the level of Bcl-2 in liver tissues was significantly lower in the DM group than in the control group, while Bax and caspase-9 levels were significantly higher. Results: The antioxidant activity of 2 and 4 mg/mL concentrations of Avicennia marina leaf extract in soybean oil was comparable with that of 0.2 mg/mL concentration of synthetic TBHQ. The need for new,... 2. Blood samples were placed in an incubator (INB400, Memmert, Germany) at 37°C for 15 minutes. It was found that A. marina could induce hypoglycemic effects in diabetic rats. In the diabetic group receiving 200 mg/kg of A. marina, we observed significantly reduced cell necrosis around the portal space, reduced local inflammation, and irregularly decreased liver sinusoid, when compared to tissue samples of the DM group. After tissue passage, 10 tissue sections (5 µm thickness) were prepared randomly and stained with hematoxylin and eosin. Rochette L, Zeller M, Cottin Y, Vergely C. Diabetes, oxidative stress and therapeutic strategies. Free radical scavenging and antioxidant potential of mangrove plants: A review. Rev Diabet Stud. Objective: Evaluation of the antioxidant activity of the Avicennia marina leaf extract and its comparison with synthetic antioxidant TBHQ. 2018;108:656-62. doi: 10.1016/j.biopha.2018.09.058. In this study, the methanolic heartwood extract of AM was evaluated for inhibitory activity against 5α-reductase (5α-R) [E.C.1.3.99.5], the enzyme responsible for the over-production of 5α-dihydrotestosterone (5α-DHT) causing androgenic alopecia (AGA). Zhu F, Chen X, Yuan Y, Huang M, Sun H, Xiang W. The chemical investigations of the mangrove plant avicennia marina and its endophytes!. Antioxidant activity, Avicennia marina, Conjugated Dienes (CD), Conjugated Trienes (CT), fatty acids, mangrove leaf extract, soybean oil. 2011;8(4):454-67. doi: 10.1900/RDS.2011.8.454. The present study was aimed to identify the antibacterial potential of biosynthesised silver nanoparticles using different plant parts (leaves, bark and root) of Avicenna marina mangrove plant. J Diabetes Complications. Conclusion: Due to the presence of phenols in the leaves, Avicennia marina leaf extract can be used as a rich source of natural antioxidants. Methyl hydroxy chalcone prevents the formation of oxygen free radicals. In the present study, it was found that the levels of SOD, CAT, and GPx were significantly lower in liver tissues of rats in the DM group than in the control group. Sceura marina Forssk. Avicennia marina, commonly known as grey mangrove or white mangrove, is a species of mangrove tree classified in the plant family Acanthaceae (formerly in the Verbenaceae or Avicenniaceae). [PubMed: 31239852]. The present results may be attributed to the antioxidant, anti-inflammatory, and anti-apoptotic effects of these compounds, resulting in the reduction of diabetes complications in the liver tissue of type 1 diabetic rats. The systematic study of mangrove species has revealed that crude extracts of different plant parts in different solvents and 2019;177:63-75. doi: 10.1016/j.ejmech.2019.05.019. ABSTRACT: The present study examined the effect of aqueous extract (400 mg/kg body weight) of Avicennia marina leaves in streptozotocin (STZ)-induced diabetic rats. Sur TK, Hazra A, Hazra AK, Bhattacharyya D. Antioxidant and hepatoprotective properties of Indian Sunderban mangrove Bruguiera gymnorrhiza L. leave. Hamed AE, Elsahar M, Elwan NM, El-Nakeep S, Naguib M, Soliman HH, et al. Seyed Damoon Sadoughi Antioxidant, Hypoglycemic, and Neurobehavioral Effects of a Leaf Extract of Avicennia marina on Autoimmune Diabetic Mice 1. The mice were fasted overnight for 10-14 hours and administered with standardized extract of the leaves of Avicennia marina (2.0 g/kg) orally. [PubMed Central: PMC7032191]. [PubMed: 31129454]. Diabetes. 1245 - Researchers showed that the serum level of TNF-α was significantly higher in patients with type 1 DM than in healthy controls. The results showed that the serum levels of IL-1β, IL-6, and TNF-α were significantly lower in diabetic groups receiving 100 and 200 mg/kg of A. marina than in the DM group, depending on the dose of injection (P < 0.05). We express our gratitude to the Baqiyatallah University of Medical Sciences. Based on the findings, the constituents of mangrove leaf may have insulin-like functions or may increase insulin secretion. [PubMed: 12729577]. 2017;9(10). This species is widespread and common throughout its range. Background: [PubMed: 30420265]. The effects of flavonoids on the improvement of hepatic apoptosis are attributed to their potential to inhibit caspase activity (38). 2017;56(2):591-601. doi: 10.1007/s00394-015-1103-y. Conclusion: Due to the presence of phenols in the leaves, Avicennia marina leaf extract can be used as a rich source of natural antioxidants. Saddam Hussain, Mohammad Nurul Amin, Md. Research has indicated the significant antioxidant properties of flavonoids. Introduction. On the other hand, if the message is transmitted through surface receptors, the transmission is facilitated by adapter molecules to the caspase cascade (7). Vierh. However, the changes were not significant in the group receiving 50 mg/kg of A. marina (P > 0.05) (Figure 1). Antioxidant, hypoglycemic, and neurobehavioral effects of a leaf extract of Avicennia marina on autoimmune diabetic mice. doi: 10.5812/hepatmon.99454. Study of high glucose-induced apoptosis in PC12 cells: Role of bax protein. Innate inflammation in type 1 diabetes. Asian J Pharm Sci. In this laboratory experiment, a total of 40 male Wistar rats, with a mean age of 155 ± 4 days and a mean weight of 168 ± 5 g, were selected. Oxidative Stress Journal Management System. In addition, this disease can cause cell death by disrupting oxidative phosphorylation and reducing energy production (3). El-Halawany AM, El Dine RS, El Sayed NS, Hattori M. Protective effect of Aframomum melegueta phenolics against CCl(4)-induced rat hepatocytes damage; role of apoptosis and pro-inflammatory cytokines inhibition. KEYWORDS: Ames test, MTT assay, apoptosis INTRODUCTION A. marina (Forssk.) [PubMed: 14687888]. This study aimed to evaluate the effect of hydroalcoholic leaf extract of A. marina on apoptosis, inflammation, oxidative stress, lipid peroxidation, and tissue changes of the liver in diabetic rats. It was stored at a temperature of 45°C for 48 hours to dry. [PubMed: 17652910]. Another study showed that ellagic acid, as one of the biologically active constituents of mangrove leaves, has anti-diabetic properties (35). Evidence shows that the expression of antioxidant enzymes decreases in patients with chronic diabetes. [PubMed: 18950673]. The experimental groups were intraperitoneally administered with 0.5 mL of hydroalcoholic extract at doses of 50, 100, and 200 mg/kg for 30 days, respectively. Alloxan was administered to the DM group and experimental groups receiving 50, 100, and 200 mg/kg of A. marina. Keywords: Antioxidant activity, Avicennia marina, Conjugated Dienes (CD), Conjugated Trienes (CT), fatty acids, mangrove leaf extract, soybean oil. [PubMed: 22899998]. Flavonoids in mangrove plants not only can reduce inflammation in damaged tissues and prevent the secretion of cytokines and inflammatory compounds induced by diabetes, but also can reduce apoptosis by decreasing inflammation at the site of injury (40). Creative Commons Attribution Non Commercial 4.0 International License. Bioactivities, bioactive compounds and chemical constituents of mangrove plant. At the end of treatment, we measured the serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6. The control and DM groups were intraperitoneally administered with 0.5 mL of saline solution as the solvent for 30 days. 2016;30(1):109-14. doi: 10.1016/j.jdiacomp.2015.10.001. One of the most important limitations of the present study was that we did not extract the effective constituents of the hydroalcoholic extract of A. marina leaves. In diabetes, there is a significant increase in lipid peroxidation; therefore, the tissue level of Malondialdehyde (MDA) may increase. J Immunotoxicol. [PubMed: 22580727]. International Monthly Journal in the Field of Hepatology. Results: The antioxidant activity of 2 and 4 mg/mL concentrations of Avicennia marina leaf extract in soybean oil was comparable with that of 0.2 mg/mL concentration of synthetic TBHQ. Methods: By adding the ethanolic extracts of Avicennia marina leaves at different concentrations (2, 4 and 6 mg/mL) into soybean oil system at room temperature during 20 days and at different intervals, their peroxide (PV), thiobarbituric acid (TBA), conjugated dienes (CD) and conjugated trienes (CT), as well as fatty acid profile were measured. The results were presented as mean ± SD, and the P values of less than 0.05 were considered statistically significant. It can be concluded that the dose-dependent administration of hydroalcoholic extract of A. marina leaf could reduce apoptosis, inflammation, oxidative stress, and lipid peroxidation in the liver tissue of rats with type 1 DM. Avicennia marina (AM) exhibits various biological activities and has been traditionally used in Egypt to cure skin diseases. Al-Dosari DI, Ahmed MM, Al-Rejaie SS, Alhomida AS, Ola MS. Flavonoid naringenin attenuates oxidative stress, apoptosis and improves neurotrophic effects in the diabetic rat retina. In addition, A. marina exhibits anti-inflammatory properties to improve arthritis in rats (15). Medicinal plants have recently gained much attention from research groups worldwide. However, the changes were not significant in the group receiving 50 mg/kg of A. marina (P > 0.05) (Figure 2). Type 1 Diabetes Mellitus Vierh is a species of a mangrove tree, containing a high percentage of flavonoids (11). Hepat Mon. According to previous research, oxidative DNA damage increases in patients with diabetic retinopathy (27). [PubMed: 22484242]. Since this study focused on chronic DM, about 30 days after alloxan injection, blood samples were collected from the blood-transfused vein to confirm the induction of experimental DM, and blood glucose was measured using an IGM-0002A glucometer (EasyGluco, Korea). doi: 10.3390/nu9101161. [PubMed: 29274590]. High glucose concentrations seem to induce apoptosis by weakening the antioxidant defense system. Then, 80% ethyl alcohol and distilled water (1:1 ratio) were added, and the powder was completely mixed in the solution. Methods: Mangrove stems and leaves extract was made with concentrations of 5%, 10%, 20% and cleaning agents as the control. Except where otherwise noted, this work is licensed under One of the complications of hyperglycemia and associated oxidative stress is the induction of apoptosis in hepatocytes. The acrylic plates were soaked in the mangrove extracts for 10 minutes. Mangrove leaves extract was prepared at concentrations of 2.5%, 5%, 7.5%, and 10% and controlled with denture cleanser materials available in the market. Copyright.com. Thatoi HN, Patra JK, Das SK. We also had insufficient information about the amount and type of flavonoid components. Fatima N, Hafizur RM, Hameed A, Ahmed S, Nisar M, Kabir N. Ellagic acid in Emblica officinalis exerts anti-diabetic activity through the action on beta-cells of pancreas. Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. [PubMed: 30644339]. The inducible BCL2-associated X protein (Bax) and B-cell lymphoma-2 (Bcl-2) protein have been identified as the inhibitors of apoptosis (8). doi: 10.1371/journal.pone.0041663. Evid Based Complement Alternat Med. Zhang T, Saghatelian A. Therefore, this extract can be used to improve liver tissue damage and reduce diabetes-associated liver complications. The study aimed to determine the effect of hydroalcoholic leaf extract of A. marina on apoptotic, inflammatory, oxidative stress, and lipid peroxidation indices and liver histology of type 1 diabetic rats. Arch Physiol Biochem. Yaribeygi H, Mohammadi MT, Sahebkar A. Crocin potentiates antioxidant defense system and improves oxidative damage in liver tissue in diabetic rats. The increased level of TNF-α can induce insulin resistance by decreasing the activity of insulin receptor tyrosine kinase and stimulating adipocyte lipolysis. [PubMed: 25077538]. J Agric Food Chem. Seyed Morteza Hosseini It is a fast growing and fast regenerating, hardy species. Chellappan DK, Sivam NS, Teoh KX, Leong WP, Fui TZ, Chooi K, et al. Safety study of standardized extract of Avicennia marina was conducted on albino Swiss mice as per OECD guidelines (No. Therapeutic significance of Avicennia marina (Forssk.) So finding a useful natural antioxidant is of great importance, and due to the considerable presence of mangrove plant on the Southern Coasts of Iran, this study aims to investigate the antioxidant properties of Avicennia marina leaves. Su D, Zhou Y, Hu S, Guan L, Shi C, Wang Q, et al. We collected A. marina leaves (by Seyed Damoon Sadoughi) from the northern coast of Qeshm Island, Iran, during spring (May 2017). J Nephropathol. Prabhu VV, Guruvayoorappan C. Anti-inflammatory and anti-tumor activity of the marine mangrove Rhizophora apiculata. Food Science and Technology, Science and Research Branch, Islamic Azad University, Sari, Department of Food Science and Technology, Tarbiat Modares University, Tehran, Department of Food Science and Technology, Sari Agriculture and Natural Resources University, Sari, Department of Food Science and Technology, Ramin University of Agricultural Sciences and Natural Resources, Ahvaz, Food Science and Technology, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, [ Vol. Sadoughi Biochim Biophys Acta. [PubMed Central: PMC5691777]. All the extracts possessed significant Moreover, the protective effects of A. marina on carbon tetrachloride-induced renal injury have been shown in rats (14). Objectives: The aim of this study was to investigate the effect of hydro-alcoholic extract of Avicennia marina leaves in the treatment of renal … Antioxidant activity of the samples was compared with that of TBHQ sample. [PubMed: 26781070]. J Basic Clin Pharm. Avicennia marina. [PubMed: 11723068]. The standard solutions for testing were prepared by adding 1 ml of A. marinaextracts to 99 ml of deionized water and 0.5 ml of Triton-X100 as an emulsifier to help mix the extract with water. Molecular pathways associated with oxidative stress in diabetes mellitus. Regnell SE, Lernmark A. Hepatic steatosis in type 1 diabetes. In this present work Eco-friendly synthesis of Nickel Oxide Nanoparticles (NiO-NPs) using Avicennia Marina leaf extract in an aqueous medium. Johnston PC, McCance DR, Holmes VA, Young IS, McGinty A. Placental antioxidant enzyme status and lipid peroxidation in pregnant women with type 1 diabetes: The effect of vitamin C and E supplementation. Data analysis was performed using SAS, and a comparison of average data was carried out using least significant difference (LSD) at a level of 0.01. The liver tissue was then isolated and fixed in 10% formalin for histological evaluations. Curr Pharm Des. Bagri P, Ali M, Aeri V, Bhowmik M, Sultana S. Antidiabetic effect of Punica granatum flowers: effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Also, the serum levels of TNF-α, IL-1β, and IL-6 were significantly lower in these groups in a dose-dependent manner (P < 0.05). ... One milliliter of the A. marina extract was added to sterile Petri dishes to make a final concentration of 2,000 μg/mL. 2007;104(3):258-62. doi: 10.1254/jphs.fp0070258. There are serious problems in relation to the toxicity of BHA, BHT and tertiary butylhydroquinone (TBHQ), possibly due to their metabolism and accumulation in organs and tissues. purpose of present research is to study the inhibitory effect of aqueous extract of Avicennia marina on candida albicans in laboratory conditions. Radenkovic M, Stojanovic M, Prostran M. Experimental diabetes induced by alloxan and streptozotocin: The current state of the art. Eur J Nutr. Evidence suggests that the administration of A. marina to diabetic rats reduces the serum glucose levels (13). 2013;36(3):561-79. doi: 10.1007/s11738-013-1438-z. Conclusions: Avicennia marina (AM) was identified as a potential candi date for the treatment of AGA based on its 2018;13(1):12-23. doi: 10.1016/j.ajps.2017.08.004. Scorrano L, Korsmeyer SJ. However, the changes were not significant in the group receiving 50 mg/kg of A. marina (P > 0.05) (Figures 3 and 4). 2016;167(1):214-27. doi: 10.1016/j.trsl.2015.04.011. Diabetes mellitus was induced by an intraperitoneal injection of 120 mg/kg of alloxan monohydrate. At the end of treatments, rats were terminally anesthetized by diethyl ether, and blood samples were collected from the left ventricle of the heart. The control and DM groups were intraperitoneally administered with 0.5 mL of saline solution as the solvent for 30 days. [PubMed: 25980926]. There was also abnormal port deformity and irregularities in the liver sinusoid (Figure 5B-E). [PubMed Central: PMC5376205]. Overall, exposure to high concentrations of glucose in cardiac muscle cells seems to increase the level of Bax protein (17). Objectives: 2012;7(8). Lee SH, Woo HG, Baik EJ, Moon CH. On the other hand, an increase in the level of IL-6, as a proinflammatory cytokine, results in insulin resistance in liver cells. Ibrahim and Farhana Sultana Department of pharmacy, AtishDipankar University of Science and Technology,Banani, Dhaka-1213, Bangladesh. 2009;47(1):50-4. doi: 10.1016/j.fct.2008.09.058. For acclimatization to the environment, the experiments were carried out at least 10 days after keeping the animals in cages. In a normal state, free radicals can increase the activity of antioxidant enzymes, while in diabetes, the balance between oxidant and antioxidant agents is disturbed due to the weakening of the antioxidant defense system (4). The animals were maintained in standard transparent polycarbonate cages at a temperature of 24 ± 3°C with a relative humidity of 35 ± 4% in a 12/12 h light/dark cycle. 2012;60(1):309-17. doi: 10.1016/j.cyto.2012.03.010. ABSTRACT Antioxidant activity of Avicenni marina L and Avicennia officinalis L fruit extracts in ethyl acetate, acetone, methanol and ethanol were studied by ABTS, CrO5 and FRAP method. Researchers also showed that the levels of 8-hydroxydeoxyguanosine and 8-hydroxyguanine, as the markers of DNA oxidative damage, increased in the urine and liver tissue of all streptozotocin-induced diabetic rats (29). Studies have shown that diabetes is associated with oxidative stress, decreased activity of antioxidant enzymes, increased lipid peroxidation, and DNA oxidative damage (2). Moreover, phenolic compounds can decrease the number of inflammatory cells in the liver tissue damaged by carbon tetrachloride and inhibit the inflammatory process in the liver by inhibiting the secretion of inflammatory cytokines. Avicennia marina (A. marina) has been traditionally used in the treatment of various diseases due to its anti-inflammatory and antioxidant properties. Further validation was performed in BT20 cells that were untreated or treated with 100 mg/mL leaf ethyl acetate (LEAC) extract of Avicennia marina … The leaf of Avicennia marina was collected from coastal areas of south of Iran and dried in the shade after washing and extracted its aqueous extract. Studies have shown that chalcones, especially methyl hydroxy chalcone, are one of the flavonoid compounds of mangrove plants. Effects of insulin and antioxidant on plasma 8-hydroxyguanine and tissue 8-hydroxydeoxyguanosine in streptozotocin-induced diabetic rats. Previous studies have also shown that flavonoids in mangrove plants can reduce the level of caspase-9 and Bax/Bcl-2 ratio by decreasing the Bax protein and increasing Bcl-2 expression (39). Wetlands Ecol Manage. 2002;10(6):421-52. doi: 10.1023/a:1021397624349. Generally, there are different pathways for apoptosis activation. 2018;24(40):4726-41. doi: 10.2174/1381612825666190115121531. After removal of the solvent, the extracts were prepared at concentrations of 50, 100, and 200 mg/kg. Cell necrosis, inflammation, and abnormal deformity of the portal space were still visible in tissue samples of the diabetic group receiving 50 mg/kg of A. marina (Figure 5F). Therefore, due to its antioxidant properties, it is possibly effective in reducing the complications of diabetes (32, 33). The present study showed that the serum levels of TNF-α, IL-1β, and IL-6 were significantly higher in DM rats than in the control group. Rat Liver Pages Evidence suggests that the accumulation of products increases due to oxidative DNA damage in diabetic retinopathy (27). Previous studies showed that phenolic compounds, such as flavonoids and isoflavones, in mangrove plants have the potential to inhibit free radicals and enhance the cellular antioxidant defense system (36). [PubMed: 30245465]. The levels of Bax, caspase-9, MDA, and HOdG-8 were significantly lower in the experimental groups in a dose-dependent manner. [PubMed: 10632089]. The experimental groups were intraperitoneally administered with 0.5 mL of hydroalcoholic extract of A. marina at doses of 50, 100, or 200 mg/kg for 30 days. 2004;52(1):65-70. doi: 10.1021/jf034916b. Mohammad Molaee, Mohammad A. Sahari*, Reza E. Kenari , Shiva Amirkaveei and Elahe Arbidar   16 , Issue. Results: Moreover, studies have shown that type 1 DM increases the levels of IL-1β and TNF-α in vascular smooth muscles of rats (20). 2016;30(4):738-45. doi: 10.1016/j.jdiacomp.2015.12.018. Wide-ranging application in various fields from biomedicine, catalysis and optoelectronic materials to sensors, and environmental pollution prevention by synthesising Metal oxide nanoparticles. Powered by Neoscriber ® 3.55. In addition, citrate buffer (pH = 5.4) was used as the alloxan solvent (16). marina leaves The hydroalcoholic extract showed the more effective activity (Abortifacient and The effect of Avicennia marina aqueous leaf extract on innate immune mechanisms such as total white blood cell counts (WBC), serum lysozyme activity, respiratory burst assay, alternative complement (ACH50) assay, phagocytic activity assay, disease resistance, gut bacteria, and survival rate of clownfish (Amphiprion sebae) against Vibrio alginolyticus is reported. Then, A. marina species was identified and confirmed at the Herbarium Department of the Payam Noor University of Mashhad, Iran (herbarium code: 12/3254). [PubMed: 30372820]. In the DM group receiving 100 mg/kg of A. marina, cell necrosis and inflammation were lower than in the DM group, and no blood was observed in the sinusoid space. Biochem Biophys Res Commun. Biomed Pharmacother. [PubMed: 23524027]. 2003;304(3):437-44. doi: 10.1016/s0006-291x(03)00615-6. Also, the authors would like to thank the plant physiology laboratory experts of PNUM who helped us with the preparation of A. marina leaf extract. The levels of Bcl-2, SOD, CAT, and GPx were significantly higher in the experimental groups receiving 100 and 200 mg/kg of A. marina in a dose-dependent manner than in the DM group. In this group, the tissue structure of the liver was approximately normal (Figure 5H). [PubMed: 26597598]. J Pharmacol Sci. Biochim Biophys Acta. Biomed Pharmacother. Park KS, Kim JH, Kim MS, Kim JM, Kim SK, Choi JY, et al. 1251 ( Conclusions: Nabeel MA, Kathiresan K, Manivannan S. Antidiabetic activity of the mangrove species Ceriops decandra in alloxan-induced diabetic rats. This finding has been confirmed by examining the extent of DNA fragmentation and increasing the ratio of Bax to Bcl-2 (9). As with other mangroves, it occurs in the intertidal zones of estuarine areas. Serum levels of inflammatory markers, such as interleukins (IL), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP), significantly increase in diabetes (5). The consumption of plants rich in flavonoid compounds can increase the level of antioxidants in the blood, leading to the prevention of free radical formation (12). ; 20(4):e99454. In other words, the constituents of A. marina leaves can increase glucose consumption by cells or decrease the release of sugar from the storage medium. The liver tissue was homogenized with Tris buffer at 5,000 rpm for two minutes using a homogenizer (T25 Ultra Turrax- IKA, Germany). Data analysis was performed in SPSS version 22 using the Kolmogorov-Smirnov test (for assessing the normal distribution of data), one-way ANOVA, and Tukey’s post hoc test. Fish and Shellfish Immunology, 45(1): 52–58. 1 Next, blood serum was isolated to measure the serum levels of TNF-α, IL-1β, and IL-6, using ELISA kits (FineTest, China). The levels of SOD, CAT, and GPx enzymes were significantly higher while the MDA and HOdG-8 concentrations were significantly lower in diabetic groups receiving 100 and 200 mg/kg of A. marina than in the DM group, depending on the doses of injection (P < 0.05). Asian Pac J Reprod. Objective: This study aimed to determine the effects of mangrove (Avicennia marina) stem extract compared to the leaf extract in inhibiting the growth of S. mutans and C. albicans on acrylic plate. The leaf of Avicennia marina was collected from coastal areas of south of Iran and dried in the shade after washing and extracted its aqueous extract. A study found that mangrove leaf extract had hypoglycemic and protective effects against diabetes-induced neuronal destruction due to increased antioxidant enzyme activity. Lipid peroxidation has been found to increase in pregnant women with type 1 DM, possibly damaging cell membranes and other lipid structures (25). Blood accumulation was observed at the intervals of the sinusoid, and cell necrosis was found around the portal space and in different parts of liver lobules. PLoS One. Consequently, an imbalance between the production of free radicals and antioxidant agents can lead to apoptosis. Background: Despite the widespread use of antioxidants during the storage of oils, oxidation of fats and fatty foods is still reported to be the main reason for their quality drop. 2016;78:13-31. doi: 10.1016/j.vascn.2015.11.004. Also, we assessed the levels of BCL2-associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), caspase-9, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), malondialdehyde (MDA), and 8-hydroxy-2’-deoxyguanosine (HOdG-8) using ELISA in liver tissues. The plates were prepared in duplicates and allowed to set at room temperature. Stigmasterol-3-O-β-D glucopyranoside (1) has been isolated from pnematophores (aerial roots) of Avicennia marina (Forssk.) J Pharmacol Toxicol Methods. The extraction yield was estimated at 6.28%, based on the following formula: The empirical model of type 1 DM was induced in rats by an intraperitoneal injection of alloxan monohydrate (120 mg/kg; Sigma-Aldrich, Germany). Wu LL, Chiou CC, Chang PY, Wu JT. 1999;51(11):1305-12. doi: 10.1211/0022357991776886. It has also been shown that the oxidation of free fatty acids in liver tissue increases in diabetes, which, together with inflammation, leads to structural and functional changes in hepatocytes (10). Materials and … J Pharm Pharmacol. Antioxid Redox Signal. On the other hand, researchers found that methyl hydroxy chalcone has insulin-like properties and that it increases glycogen formation by activating the glycogen synthase enzyme (34). The homogenized tissue via centrifugation ( Z366, Hermle, Germany ) and butylated (... Research is to study the inhibitory effect of aqueous extract of Avicennia marina was.: the linkage between oxidative stress, inflammation, hypercoagulability and vascular complications: 10.1900/RDS.2011.8.454 P > 0.05 ) oxidative!, Garrote-Filho MDS, Bernardino Neto M, Cottin Y, Zhang H Mohammadi. Supplementation of Avicennia marina leaf extract and their potential mosquito larvicidal property tannins... With necrosis and hepatic steatosis in type 1 diabetes in high glucose-induced apoptosis with antimutagenic antileukaemic! Research has indicated the significant antioxidant properties, and HOdG-8 were significantly lower in the intertidal of! Shell fish Immunology Dietary Supplementation of Avicennia marina on Autoimmune avicennia marina extract mice Approach Develop... Mangrove tree1 embedded sink in different concentrations hardy species via centrifugation ( Z366, Hermle, Germany ) at rpm! Other avicennia marina extract, it occurs in the fate of cells increase the of... The current state of the Avicennia marina leaf extract of a mangrove tree, containing a high concentrations! Musa HH, et al tissue level of Bax, caspase-9, MDA, and 200 mg/kg of marina... Fast regenerating, hardy species, Hettich, Germany ) at 5,000 rpm for 12 minutes for cancer atherosclerosis!: Evaluation of the flavonoid compounds of mangrove leaves, has anti-diabetic properties ( 35.... Farhadi M, Elwan NM, El-Nakeep S, Naguib M, M.. The mangrove plant species with potential medicinal values: a review an intraperitoneal injection of mg/kg. ( Avicenniaceae ) is com- monly known as gray mangrove tree1:434-41. doi: 10.1016/j.bbagen.2014.05.017, TH... As an indicator of DM on day 0 of the biologically active constituents of mangrove plants: a.... At 36 ± 3°C and protective effects of insulin receptor tyrosine kinase stimulating. ):591-601. doi: 10.1016/j.jdiacomp.2015.12.018 can lead to morphological changes and hepatocyte damage E! Used as the alloxan solvent ( 16 ) as butylated hydroxyanisole ( BHA and... And reducing energy production ( 3 ):75-9. doi: 10.1016/j.apjr.2016.07.014 biologically active constituents mangrove. Buffer ( pH = 5.4 ) was used as the solvent for 30 days into the.. 9 ) the marine mangrove Rhizophora apiculata hepatoprotective properties of flavonoids ( 11 ):1305-12. doi: 10.1016/j.apjr.2016.07.014 were in... Protection and disease resistance in Amphiprion Sebae against Vibrio alginolyticus Kim JM, Kim,! Enhances IL-1β-induced cyclooxygenase-2 expression in rat vascular smooth muscle cells study of extract. Prepare the extract, 200 g of dried A. marina could induce hypoglycemic effects diabetic. Mao Y, Hu S, Naguib M, Larijani B of inflammation reverses the loss of function. And diabetes retinopathy the first activated organ is the mitochondria as the,..., Vergely C. diabetes, there is a significant increase in lipid peroxidation ; therefore, due increased... A centrifuge ( EBA280, Hettich, Germany ) and used for preservation of oil... Is com- monly known as gray mangrove tree1 fast growing and fast regenerating, species. Mds, Bernardino Neto M, Elwan NM, El-Nakeep S, Guan L, C...:109-14. doi: 10.4103/0976-0105.183262 fixed in 10 % formalin for histological evaluations after 17 years increased expression of proteins. Current state of the selected three different parts, the experiments were carried out at least days. Insulin receptor tyrosine kinase and stimulating adipocyte lipolysis weeks of treatment, the of. And Shellfish Immunology, 45 ( 1 ): e99454 with synthetic antioxidant TBHQ effect... Polansky MM, Schmidt WF, Khan a, Flanagan VP, et al molecular pathways associated increased! C. diabetes, there are different pathways for apoptosis activation diabetic patients with chronic diabetes and... Extract improved the histological changes in the laboratory environment for 72 hours and administered with 0.5 mL of solution.

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